Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in <i>CNTNAP2</i> -deficient mice
Aslihan Selimbeyoglu(Stanford University), Christina K. Kim(Stanford University), Masatoshi Inoue(Stanford University), Soo Yeun Lee(Stanford University), Alice Hong(Stanford University), Isaac Kauvar(Stanford University), Charu Ramakrishnan(Stanford University), Lief E. Fenno(Stanford University), Thomas J. Davidson(Stanford University), Matthew A. Wright(Stanford University), Karl Deisseroth(Howard Hughes Medical Institute)
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Abstract
knockout mice. Together, these results suggest that real-time modulation of E:I balance in the mouse prefrontal cortex can rescue social behavior deficits reminiscent of autism phenotypes.
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