tsRNA signatures in cancer

Veronica Balatti(The Ohio State University), Giovanni Nigita(The Ohio State University), Dario Veneziano(The Ohio State University), Alessandra Drusco(The Ohio State University), Gary S. Stein(University of Vermont), Terri Messier(University of Vermont), Nicholas H. Farina(University of Vermont), Jane B. Lian(University of Vermont), Luisa Tomasello(The Ohio State University), Chang‐Gong Liu(The University of Texas MD Anderson Cancer Center), Alexey Palamarchuk(The Ohio State University), Jonathan R. Hart(Scripps Research Institute), Catherine Bell(Scripps Research Institute), Mariantonia Carosi, Edoardo Pescarmona, Letizia Perracchio, Maria Grazia Diodoro, Andrea Russo, Anna Antenucci, Paolo Visca, Antonio Ciardi(Sapienza University of Rome), Curtis C. Harris(National Institutes of Health), Peter K. Vogt(Scripps Research Institute), Yuri Pekarsky(The Ohio State University), Carlo M. Croce(The Ohio State University)
Proceedings of the National Academy of Sciences
July 10, 2017
10.1073/pnas.1706908114
Cited by 289Open Access
Full Text

Abstract

Significance We found that tRNA-derived small RNAs (tsRNAs) are dysregulated in many cancers and that their expression is modulated during cancer development and staging. Indeed, activation of oncogenes and inactivation of tumor suppressors lead to a dysregulation of specific tsRNAs, and tsRNA-KO cells display a specific change in gene-expression profile. Thus tsRNAs could be key effectors in cancer-related pathways. These results indicate active crosstalk between tsRNAs and oncogenes and suggest that tsRNAs could be useful markers for diagnosis or targets for therapy. Additionally, ts-46 and ts-47 affect cell growth in lung cancer cell lines, further confirming the involvement of tsRNAs in cancer pathogenesis.

Related Papers

No related papers found

Powered by citation graph analysis