Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry
Takaya Moriyama(St. Jude Children's Research Hospital), Yung‐Li Yang(National Taiwan University Hospital), Rina Nishii(Tokyo Medical and Dental University), Hany Ariffin(University Malaya Medical Centre), Chengcheng Liu(St. Jude Children's Research Hospital), Ting-Nien Lin(St. Jude Children's Research Hospital), Wenjian Yang(St. Jude Children's Research Hospital), Dong‐Tsamn Lin(National Taiwan University Hospital), Chih‐Hsiang Yu(National Taiwan University), Shirley Kow Yin Kham(National University Cancer Institute, Singapore), Ching‐Hon Pui(St. Jude Children's Research Hospital), William E. Evans(St. Jude Children's Research Hospital), Sima Jeha(St. Jude Children's Research Hospital), Mary V. Relling(St. Jude Children's Research Hospital), Allen Eng Juh Yeoh(National University of Singapore), Jun J. Yang(St. Jude Children's Research Hospital)
Cited by 107Open Access
Abstract
Key Points We identified 3 novel loss-of-function variants in NUDT15 linked to thiopurine intolerance. Our findings extended the importance of NUDT15 variation in thiopurine pharmacogenetics in diverse populations.
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