Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain

Siling Liu(Kunming Institute of Zoology), Zhengbo Wang(Kunming Institute of Zoology), Dong Chen(Genetic Analysis (Norway)), Bowen Zhang(University of Science and Technology of China), Ren‐Rong Tian(Kunming Institute of Zoology), Jing Wu(Kunming Institute of Zoology), Ying Zhang(Kunming Institute of Zoology), Kaiyu Xu(Kunming Institute of Zoology), Liu‐Meng Yang(Kunming Institute of Zoology), Chao Cheng(Genetic Analysis (Norway)), Jian Ma(Kunming Institute of Zoology), Longbao Lv(Kunming Institute of Zoology), Yong‐Tang Zheng(Kunming Institute of Zoology), Xintian Hu(Kunming Institute of Zoology), Yi Zhang(Kunming Institute of Zoology), Xiangting Wang(University of Science and Technology of China), Jiali Li(Kunming Institute of Zoology)
Genome Research
July 7, 2017
10.1101/gr.217463.116
Cited by 157Open Access
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Abstract

Long noncoding RNAs (lncRNAs) mediate important epigenetic regulation in a wide range of biological processes and diseases. We applied comprehensive analyses of RNA-seq and CAGE-seq (cap analysis of gene expression and sequencing) to characterize the dynamic changes in lncRNA expression in rhesus macaque ( Macaca mulatta ) brain in four representative age groups. We identified 18 anatomically diverse lncRNA modules and 14 mRNA modules representing spatial, age, and sex specificities. Spatiotemporal- and sex-biased changes in lncRNA expression were generally higher than those observed in mRNA expression. A negative correlation between lncRNA and mRNA expression in cerebral cortex was observed and functionally validated. Our findings offer a fresh insight into spatial-, age-, and sex-biased changes in lncRNA expression in macaque brain and suggest that the changes represent a previously unappreciated regulatory system that potentially contributes to brain development and aging.

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