Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

Uğur Şahin; Evelyna Derhovanessian; Matthias Miller; Björn‐Philipp Kloke; Petra Simon; Martin Löwer; Valesca Bukur; Arbel D. Tadmor; Ulrich Luxemburger; Barbara Schrörs; Tana Omokoko; Mathias Vormehr; Christian Albrecht; Anna Paruzynski; Andreas N. Kuhn; Janina Buck; Sandra Heesch; Katharina Schreeb; Felicitas Müller; Inga Ortseifer; Isabel Vogler; Eva Godehardt; Sebastian Attig; Richard Rae; Andrea Breitkreuz; Claudia Tolliver; M Suchan; Goran Martic; Alexander Hohberger; Patrick Sorn; Jan Diekmann; Janko Ciesla; Olga Waksmann; Alexandra-Kemmer Brück; Meike Witt; Martina Zillgen; Andrée Rothermel; Barbara Kasemann; David Langer; Stefanie Bolte; Mustafa Diken; Sebastian Kreiter; Romina Nemecek; Christoffer Gebhardt; Stephan Grabbe; Christoph Höller; Jochen Utikal; Christoph Huber; Carmen Loquai; Özlem Türeci

doi:10.1038/nature23003

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

Uğur Şahin(BioNTech (Germany)), Evelyna Derhovanessian(BioNTech (Germany)), Matthias Miller(BioNTech (Germany)), Björn‐Philipp Kloke(BioNTech (Germany)), Petra Simon(BioNTech (Germany)), Martin Löwer(University Medical Center of the Johannes Gutenberg University Mainz), Valesca Bukur(BioNTech (Germany)), Arbel D. Tadmor(University Medical Center of the Johannes Gutenberg University Mainz), Ulrich Luxemburger(BioNTech (Germany)), Barbara Schrörs(University Medical Center of the Johannes Gutenberg University Mainz), Tana Omokoko(BioNTech (Germany)), Mathias Vormehr(BioNTech (Germany)), Christian Albrecht(Johannes Gutenberg University Mainz), Anna Paruzynski(BioNTech (Germany)), Andreas N. Kuhn(BioNTech (Germany)), Janina Buck(BioNTech (Germany)), Sandra Heesch(BioNTech (Germany)), Katharina Schreeb(BioNTech (Germany)), Felicitas Müller(BioNTech (Germany)), Inga Ortseifer(BioNTech (Germany)), Isabel Vogler(BioNTech (Germany)), Eva Godehardt(BioNTech (Germany)), Sebastian Attig(University Medical Center of the Johannes Gutenberg University Mainz), Richard Rae(Johannes Gutenberg University Mainz), Andrea Breitkreuz(BioNTech (Germany)), Claudia Tolliver(BioNTech (Germany)), M Suchan(University Medical Center of the Johannes Gutenberg University Mainz), Goran Martic(University Medical Center of the Johannes Gutenberg University Mainz), Alexander Hohberger(Johannes Gutenberg University Mainz), Patrick Sorn(University Medical Center of the Johannes Gutenberg University Mainz), Jan Diekmann(BioNTech (Germany)), Janko Ciesla(Forschungsinstitut für Mineralische und Metallische Werkstoffe Edelsteine/Edemetalle), Olga Waksmann(Forschungsinstitut für Mineralische und Metallische Werkstoffe Edelsteine/Edemetalle), Alexandra-Kemmer Brück(BioNTech (Germany)), Meike Witt(BioNTech (Germany)), Martina Zillgen(BioNTech (Germany)), Andrée Rothermel(University Medical Center of the Johannes Gutenberg University Mainz), Barbara Kasemann(Johannes Gutenberg University Mainz), David Langer(BioNTech (Germany)), Stefanie Bolte(BioNTech (Germany)), Mustafa Diken(Johannes Gutenberg University Mainz), Sebastian Kreiter(BioNTech (Germany)), Romina Nemecek(Medical University of Vienna), Christoffer Gebhardt(German Cancer Research Center), Stephan Grabbe(Johannes Gutenberg University Mainz), Christoph Höller(Medical University of Vienna), Jochen Utikal(Heidelberg University), Christoph Huber(BioNTech (Germany)), Carmen Loquai(Johannes Gutenberg University Mainz), Özlem Türeci

Nature

July 4, 2017

10.1038/nature23003

Cited by 2,436

Abstract

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