Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages
Kelly Kersten(The Netherlands Cancer Institute), Seth B. Coffelt(The Netherlands Cancer Institute), Marlous Hoogstraat(The Netherlands Cancer Institute), Niels J. M. Verstegen(The Netherlands Cancer Institute), Kim Vrijland(The Netherlands Cancer Institute), Metamia Ciampricotti(The Netherlands Cancer Institute), Chris W. Doornebal(Amsterdam UMC Location University of Amsterdam), Cheei‐Sing Hau(The Netherlands Cancer Institute), Max D. Wellenstein(The Netherlands Cancer Institute), Camilla Salvagno(The Netherlands Cancer Institute), Parul Doshi(Janssen (United States)), Esther H. Lips(The Netherlands Cancer Institute), Lodewyk F.A. Wessels(The Netherlands Cancer Institute), Karin E. de Visser(The Netherlands Cancer Institute)
Cited by 104Open Access
Abstract
T cell activity. These results highlight a new role for CCL2 in facilitating the breast cancer-induced pro-metastatic systemic inflammatory γδ T cell - IL17 - neutrophil axis.
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