Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

Nobuhiro Nakai; Masatoshi Nagano; Fumihito Saitow; Yasuhito Watanabe; Yoshinobu Kawamura; Akiko Kawamoto; Kota Tamada; Hiroshi Mizuma; Hirotaka Onoe; Yasuyoshi Watanabe; Hiromu Monai; Hajime Hirase; Jin Nakatani; Hirofumi Inagaki; Tomoyuki Kawada; Taisuke Miyazaki; Masahiko Watanabe; Yuka Sato; Shigeo Okabe; K. Kitamura; Masanobu Kano; Kouichi Hashimoto; Hidenori Suzuki; Toru Takumi

doi:10.1126/sciadv.1603001

Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

Nobuhiro Nakai(Hiroshima University), Masatoshi Nagano(Nippon Medical School), Fumihito Saitow(Nippon Medical School), Yasuhito Watanabe(Hiroshima University), Yoshinobu Kawamura(Hiroshima University), Akiko Kawamoto(Hiroshima University), Kota Tamada(Hiroshima University), Hiroshi Mizuma(CE Technologies (United Kingdom)), Hirotaka Onoe(CE Technologies (United Kingdom)), Yasuyoshi Watanabe(Hiroshima University), Hiromu Monai(RIKEN Center for Brain Science), Hajime Hirase(RIKEN Center for Brain Science), Jin Nakatani(Shiga University of Medical Science), Hirofumi Inagaki(Nippon Medical School), Tomoyuki Kawada(Nippon Medical School), Taisuke Miyazaki(Hokkaido University), Masahiko Watanabe(Hokkaido University), Yuka Sato(The University of Tokyo), Shigeo Okabe(The University of Tokyo), K. Kitamura(The University of Tokyo), Masanobu Kano(The University of Tokyo), Kouichi Hashimoto(Hiroshima University), Hidenori Suzuki(Japan Science and Technology Agency), Toru Takumi(Hiroshima University)

Science Advances

June 2, 2017

10.1126/sciadv.1603001

Cited by 84Open Access

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Abstract

mice revealed the reversibility of a subset of ASD-related symptoms in the adult. These findings suggest that serotonin may have therapeutic potential for discrete ASD symptoms.

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