Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study
Tamir Kanias(University of Pittsburgh), Marion C. Lanteri(University of California, San Francisco), Grier P. Page(RTI International), Yuelong Guo(RTI International), Stacy Endres‐Dighe(RTI International), Mars Stone(University of California, San Francisco), Sheila M. Keating(University of California, San Francisco), Alan E. Mast(Medical College of Wisconsin), Ritchard G. Cable(American Red Cross), Darrell J. Triulzi(University of Pittsburgh), Joseph E. Kiss(Institute for Transfusion Medicine), Edward L. Murphy(University of California, San Francisco), Steve Kleinman(University of British Columbia), Michael P. Busch(University of California, San Francisco), Mark T. Gladwin(University of Pittsburgh)
Cited by 220Open Access
Abstract
< .0001). Donor race/ethnicity was also associated with extreme (>1%) levels of storage hemolysis exceeding US Food and Drug Administration regulations for transfusion (hemolysis >1% was observed in 3.51% of Asian and 2.47% of African American donors vs 1.67% of white donors). These findings highlight the impact of donor genetic traits on measures of RBC hemolysis during routine cold storage, and they support current plans for genome-wide association studies, which may help identify hereditable variants with substantive effects on RBC storage stability and possibly posttransfusion outcomes.
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