Carbon dots for tracking and promoting the osteogenic differentiation of mesenchymal stem cells
Dan Shao(Jilin University), Mengmeng Lu(Jilin University), Duo Xu(Jilin University), Xiao Zheng(Jilin University), Yue Pan(Jilin University), Yubin Song(Jilin University), Jinying Xu(Jilin University), Mingqiang Li(Columbia University), Ming Zhang(Jilin University), Jing Li(Jilin University), Guangfan Chi(Jilin University), Li Chen(Jilin University), Bai Yang(Jilin University)
Cited by 129
Abstract
. Importantly, the presence of the CDs and Et-IPCA facilitates high-efficiency osteogenic differentiation of rBMSCs by promoting osteogenic transcription and enhancing matrix mineralization. Compared to Et-IPCA, CDs considerably provide long-term tracking and promote the differentiation of rBMSCs toward osteoblasts through the ROS-mediated MAPK pathway. Taken together, our results consistently demonstrate that carbon dots are capable of both tracking and enhancing the osteogenic differentiation of MSCs. This study sheds new light on the potential of carbon dots as a bifunctional tool in the thriving field of MSC-based therapy.
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