Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease
Michael R. Jones(University of Calgary), Émilie Mathieu(Simon Fraser University), Christine Dyrager(Simon Fraser University), Simon Faissner(Allen Institute for Brain Science), Zavier Vaillancourt(Simon Fraser University), Kyle J. Korshavn(University of Michigan), Mi Hee Lim(Ulsan National Institute of Science and Technology), Ayyalusamy Ramamoorthy(University of Michigan), V. Wee Yong(Allen Institute for Brain Science), Shigeki Tsutsui(Allen Institute for Brain Science), Peter K. Stys(Allen Institute for Brain Science), Tim Storr(Simon Fraser University)
Cited by 93Open Access
Abstract
click chemistry, highlights the influence of R-group modification on ligand-Aβ interactions and neuroprotective effects. Overall, this study demonstrates that the phenol-triazole ligand scaffold can target multiple factors associated with AD, thus warranting further therapeutic development.
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