Model membrane size-dependent amyloidogenesis of Alzheimer's amyloid-β peptides
Misaki Kinoshita(Suita Municipal Hospital), Erina Kakimoto(Suita Municipal Hospital), Mayu S. Terakawa(Cornell University), Yuxi Lin(Suita Municipal Hospital), Tatsuya Ikenoue(University of Cambridge), Masatomo So(Suita Municipal Hospital), Toshihiko Sugiki(Suita Municipal Hospital), Ayyalusamy Ramamoorthy(University of Michigan), Yuji Goto(Suita Municipal Hospital), Young‐Ho Lee(Suita Municipal Hospital)
Cited by 49
Abstract
amyloidogenicity on vesicles. We proposed comprehensive models for vesicle size-dependent Aβ amyloidogenesis. Inhomogeneous packing defects in SUVs may induce distinct nucleation in the polymorphisms of amyloids and decreasing local concentrations of Aβ with higher amounts of LUVs inhibits amyloid formation. We also pointed out that C-terminal hydrophobicity of Aβ is important for amyloidogenesis on membranes.
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