Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer

Likun Li; Styliani Karanika; Guang Yang; Jiangxiang Wang; Sanghee Park; Bradley M. Broom; Ganiraju C. Manyam; Wenhui Wu; Yong Luo; Spyridon P. Basourakos; Jian H. Song; Gary E. Gallick; Theodoros Karantanos; Dimitrios Korentzelos; Abul Kalam Azad; Jeri Kim; Paul G. Corn; Ana M. Aparicio; Christopher J. Logothetis; Patricia Troncoso; Timothy P. Heffernan; Carlo Toniatti; Hyun‐Sung Lee; Ju‐Seog Lee; Xuemei Zuo; Wenjun Chang; Jianhua Yin; Timothy C. Thompson

doi:10.1126/scisignal.aam7479

Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer

Likun Li(The University of Texas MD Anderson Cancer Center), Styliani Karanika(The University of Texas MD Anderson Cancer Center), Guang Yang(The University of Texas MD Anderson Cancer Center), Jiangxiang Wang(The University of Texas MD Anderson Cancer Center), Sanghee Park(The University of Texas MD Anderson Cancer Center), Bradley M. Broom(The University of Texas MD Anderson Cancer Center), Ganiraju C. Manyam(The University of Texas MD Anderson Cancer Center), Wenhui Wu(The University of Texas MD Anderson Cancer Center), Yong Luo(The University of Texas MD Anderson Cancer Center), Spyridon P. Basourakos(The University of Texas MD Anderson Cancer Center), Jian H. Song(The University of Texas MD Anderson Cancer Center), Gary E. Gallick(The University of Texas MD Anderson Cancer Center), Theodoros Karantanos(The University of Texas MD Anderson Cancer Center), Dimitrios Korentzelos(The University of Texas MD Anderson Cancer Center), Abul Kalam Azad(The University of Texas MD Anderson Cancer Center), Jeri Kim(The University of Texas MD Anderson Cancer Center), Paul G. Corn(The University of Texas MD Anderson Cancer Center), Ana M. Aparicio(The University of Texas MD Anderson Cancer Center), Christopher J. Logothetis(The University of Texas MD Anderson Cancer Center), Patricia Troncoso(The University of Texas MD Anderson Cancer Center), Timothy P. Heffernan(The University of Texas MD Anderson Cancer Center), Carlo Toniatti(The University of Texas MD Anderson Cancer Center), Hyun‐Sung Lee(The University of Texas MD Anderson Cancer Center), Ju‐Seog Lee(The University of Texas MD Anderson Cancer Center), Xuemei Zuo(The University of Texas MD Anderson Cancer Center), Wenjun Chang(The University of Texas MD Anderson Cancer Center), Jianhua Yin(The University of Texas MD Anderson Cancer Center), Timothy C. Thompson(The University of Texas MD Anderson Cancer Center)

Science Signaling

May 23, 2017

10.1126/scisignal.aam7479

Cited by 304

Abstract

Androgen receptor inhibition induces a “BRCAness” state that may be exploited with PARP inhibitors in patients with advanced prostate cancer.

Related Papers

No related papers found

Powered by citation graph analysis