Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Anubha Mahajan(Centre for Human Genetics), Jennifer Wessel(Indiana University – Purdue University Indianapolis), Sara M. Willems(University of Cambridge), Wei Zhao(University of Pennsylvania), Neil R. Robertson(Centre for Human Genetics), Audrey Y. Chu(Brigham and Women's Hospital), Wei Gan(Centre for Human Genetics), Hidetoshi Kitajima(Centre for Human Genetics), Daniel Taliun(University of Michigan), Nigel W. Rayner(Centre for Human Genetics), Xiuqing Guo(The Lundquist Institute), Yingchang Lu(Icahn School of Medicine at Mount Sinai), Man Li(Brigham and Women's Hospital), Richard A. Jensen(University of Washington), Yao Hu(Chinese Academy of Sciences), Shaofeng Huo(Chinese Academy of Sciences), Kurt K. Lohman(Wake Forest University), Weihua Zhang(Ealing Hospital), James P. Cook(University of Liverpool), Bram P. Prins(Wellcome Sanger Institute), Jason Flannick(Broad Institute), Niels Grarup(University of Copenhagen), Vassily Trubetskoy(University of Michigan), Jasmina Kravić(Lund University), Young Jin Kim(Korea National Institute of Health), Denis Rybin(Boston University), Hanieh Yaghootkar(University of Exeter), Martina Müller‐Nurasyid(Helmholtz Zentrum München), Karina Meidtner(Deutsches Diabetes-Zentrum e.V.), Ruifang Li‐Gao(Leiden University Medical Center), Tibor V. Varga(Lund University), Jonathan Marten(Institute of Genetics and Cancer), Jin Li(Stanford University), Albert V. Smith(University of Iceland), Ping An(Washington University in St. Louis), Symen Ligthart(Erasmus MC), Stefan Gustafsson(Uppsala University), Giovanni Malerba(University of Verona), Ayşe Demirkan(Leiden University Medical Center), Juan Fernández Tajes(Centre for Human Genetics), Valgerður Steinthórsdóttir(deCODE Genetics (Iceland)), Matthias Wuttke(University of Freiburg), Cécile Lecoeur(Centre National de la Recherche Scientifique), Michael Preuß(Icahn School of Medicine at Mount Sinai), Lawrence F. Bielak(University of Michigan), Marielisa Graff(University of North Carolina at Chapel Hill), Heather M. Highland(The University of Texas Health Science Center at Houston), Anne E. Justice(University of North Carolina at Chapel Hill), Dajiang J. Liu(Pennsylvania State University), Eirini Marouli(Queen Mary University of London), Gina M. Peloso(Broad Institute), Helen Warren(Queen Mary University of London), Saima Afaq(Imperial College London), Shoaib Afzal(University of Copenhagen), Emma Ahlqvist(Lund University), Peter Almgren(Lund University), Najaf Amin(Erasmus MC), Lia B. Bang(Copenhagen University Hospital), Alain G. Bertoni(Wake Forest University), Cristina Bombieri(University of Verona), Jette Bork‐Jensen(University of Copenhagen), Ivan Brandslund(University of Southern Denmark), Jennifer A. Brody(University of Washington), Noël P. Burtt(Broad Institute), Mickaël Canouil(Centre National de la Recherche Scientifique), Yii‐Der Ida Chen(The Lundquist Institute), Yoon Shin Cho(Hallym University), Cramer Christensen(Lillebaelt Hospital), Sophie V. Eastwood(University College London), Kai‐Uwe Eckardt(Charité - Universitätsmedizin Berlin), Krista Fischer(University of Tartu), Giovanni Gambaro(Università Cattolica del Sacro Cuore), Vilmantas Giedraitis(Uppsala University), Megan L. Grove(The University of Texas Health Science Center at Houston), Hugoline G. de Haan(Leiden University Medical Center), Sophie Hackinger(Wellcome Sanger Institute), Yang Hai(The Lundquist Institute), Sohee Han(Korea National Institute of Health), Anne Tybjærg‐Hansen(University of Copenhagen), Marie‐France Hivert(Université de Sherbrooke), Bo Isomaa(Folkhälsans Forskningscentrum), Susanne Jäger(Deutsches Diabetes-Zentrum e.V.), Marit E. Jørgensen(Steno Diabetes Centers), Torben Jørgensen(University of Copenhagen), Annemari Käräjämäki(Vaasa Central Hospital), Bong-Jo Kim(Korea National Institute of Health), Sung Soo Kim(Korea National Institute of Health), Heikki A. Koistinen(University of Helsinki), Péter Kovács(IFB Adiposity Diseases), Jennifer Kriebel(Helmholtz Zentrum München), Florian Kronenberg(Innsbruck Medical University), Kristi Läll(University of Tartu), Leslie A. Lange(University of Colorado Denver), Jung‐Jin Lee(University of Pennsylvania), Benjamin Lehne(Imperial College London), Huaixing Li(Chinese Academy of Sciences), Keng‐Hung Lin(Taichung Veterans General Hospital), Allan Linneberg(University of Copenhagen), Ching‐Ti Liu(Boston University), Jun Liu(Erasmus MC), Marie Loh(Agency for Science, Technology and Research), Reedik Mägi(University of Tartu), Vasiliki Mamakou(National and Kapodistrian University of Athens), Roberta McKean‐Cowdin(University of Southern California), Girish N. Nadkarni(Icahn School of Medicine at Mount Sinai), Matt J. Neville(University of Oxford), Sune F. Nielsen(University of Copenhagen), Ιωάννα Ντάλλα(Queen Mary University of London), Patricia A. Peyser(University of Michigan), Wolfgang Rathmann(Deutsches Diabetes-Zentrum e.V.), Kenneth Rice(University of Washington), Stephen S. Rich(University of Virginia), Line Rode(Copenhagen University Hospital), Olov Rolandsson(Umeå University), Sebastian Schönherr(Innsbruck Medical University), Elizabeth Selvin(Johns Hopkins University), Kerrin S. Small(King's College London), Alena Stančáková(University of Eastern Finland), Praveen Surendran(University of Cambridge), Kent D. Taylor(The Lundquist Institute), Tanya M. Teslovich(University of Michigan), Barbara Thorand(Helmholtz Zentrum München), Guðmar Þorleifsson(deCODE Genetics (Iceland)), Adrienne Tin(Johns Hopkins University), Anke Tönjes(Leipzig University), Anette Varbo(University of Copenhagen), Daniel R. Witte(Aarhus University), Andrew R. Wood(University of Exeter), Pranav Yajnik(University of Michigan), Jie Yao(The Lundquist Institute), Loïc Yengo(Centre National de la Recherche Scientifique), Robin Young(University of Cambridge), Philippe Amouyel(Inserm), Heiner Boeing(German Institute of Human Nutrition), Eric Boerwinkle(Baylor College of Medicine), Erwin P. Böttinger(Icahn School of Medicine at Mount Sinai), Rajiv Chowdhury(University of Cambridge), Francis S. Collins(National Institutes of Health), George Dedoussis(Harokopio University of Athens), Abbas Dehghan(Erasmus MC), Panos Deloukas(Queen Mary University of London), Maurizio Ferrario(University of Insubria), Jean Ferrières(Inserm), José C. Florez(Broad Institute), Philippe Frossard(Center for Non-Communicable Diseases), Vilmundur Guðnason(University of Iceland), Tamara B. Harris(National Institutes of Health), Susan R. Heckbert(University of Washington), Joanna M. M. Howson(University of Cambridge), Martin Ingelsson(Uppsala University), Sekar Kathiresan(Broad Institute), Frank Kee(Queen's University Belfast), Johanna Kuusisto(University of Eastern Finland), Claudia Langenberg(University of Cambridge), Lenore J. Launer(National Institutes of Health), Cecilia M. Lindgren(Broad Institute), Satu Männistö(Finnish Institute for Health and Welfare), Thomas Meitinger(Helmholtz Zentrum München), Olle Melander(Lund University), Karen L. Mohlke(University of North Carolina at Chapel Hill), Marie Moitry(Université de Strasbourg), Andrew D. Morris(Centre for Human Genetics), Alison D. Murray(University of Aberdeen), Renée de Mutsert(Leiden University Medical Center), Marju Orho‐Melander(Lund University), Katharine R. Owen(University of Oxford), Markus Perola(University of Helsinki), Annette Peters(Helmholtz Zentrum München), Michael A. Province(Washington University in St. Louis), Asif Rasheed(Center for Non-Communicable Diseases), Paul M. Ridker(Brigham and Women's Hospital), Fernando Rivadineira(Erasmus MC), Frits R. Rosendaal(Leiden University Medical Center), Anders H. Rosengren(Lund University), Veikko Salomaa(Finnish Institute for Health and Welfare), Wayne H.-H. Sheu(National Yang Ming Chiao Tung University), Robert Sladek(McGill University and Génome Québec Innovation Centre), Blair H. Smith(University of Dundee), Konstantin Strauch(Helmholtz Zentrum München), André G. Uitterlinden(Uppsala University), Rohit Varma(University of Southern California), Cristen J. Willer(University of Michigan), Matthias Blüher(IFB Adiposity Diseases), Adam S. Butterworth(University of Cambridge), John C. Chambers(Imperial College Healthcare NHS Trust), Daniel I. Chasman(Brigham and Women's Hospital), John Danesh(University of Cambridge), Cornelia M. van Duijn(Erasmus MC), Josée Dupuis(Boston University), Oscar H. Franco(Erasmus MC), Paul W. Franks(Harvard University), Philippe Froguel(Centre National de la Recherche Scientifique), Harald Grallert(Helmholtz Zentrum München), Leif Groop(University of Helsinki), Bok‐Ghee Han(Korea National Institute of Health), Torben Hansen(University of Copenhagen), Andrew T. Hattersley(University of Exeter), Caroline Hayward(Institute of Genetics and Cancer), Erik Ingelsson(Uppsala University), Sharon L. R. Kardia(University of Michigan), Fredrik Karpe(University of Oxford), Jaspal S. Kooner(Imperial College Healthcare NHS Trust), Anna Köttgen(University of Freiburg), Kari Kuulasmaa(Technical University of Munich), Markku Laakso(University of Eastern Finland), Lin Xu(Chinese Academy of Sciences), Lars Lind(Uppsala University), Ching‐Ti Liu(Wake Forest University), Ruth J. F. Loos(Child Health and Development Institute), Jonathan Marchini(Centre for Human Genetics), Andres Metspalu(University of Tartu), Dennis O. Mook‐Kanamori(Leiden University Medical Center), Børge G. Nordestgaard(University of Copenhagen), Colin N. A. Palmer(University of Dundee), James S. Pankow(University of Minnesota), Oluf Pedersen(University of Copenhagen), Bruce M. Psaty(Kaiser Permanente Washington Health Research Institute), Rainer Rauramaa, Naveed Sattar(University of Glasgow), Matthias B. Schulze(Deutsches Diabetes-Zentrum e.V.), Nicole Soranzo(University of Cambridge), Timothy D. Spector(King's College London), Kāri Stefánsson(deCODE Genetics (Iceland)), Michael Stümvoll(University Hospital Leipzig), Unnur Þorsteinsdóttir(deCODE Genetics (Iceland)), Tiinamaija Tuomi(University of Helsinki), Jaakko Tuomilehto(Universität für Weiterbildung Krems), Nicholas J. Wareham(University of Cambridge), James Wilson(Jackson Memorial Hospital), Eleftheria Zeggini(Wellcome Sanger Institute), Robert A. Scott(University of Cambridge), Inês Barroso(University of Cambridge), Timothy M. Frayling(University of Exeter), Mark O. Goodarzi(Cedars-Sinai Medical Center), James B. Meigs(Harvard University), Michael Boehnke(University of Michigan), Danish Saleheen(Center for Non-Communicable Diseases), Andrew P. Morris(Centre for Human Genetics), Jerome I. Rotter(The Lundquist Institute), Mark I. McCarthy(Centre for Human Genetics)
Nature Genetics
April 1, 2018
Cited by 469Open Access
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