Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathies
Jianlan Gu(New York State Office for People With Developmental Disabilities), Feng Chen(New York State Office for People With Developmental Disabilities), Khalid Iqbal(New York State Office for People With Developmental Disabilities), Cheng-Xin Gong(New York State Office for People With Developmental Disabilities), Xinglong Wang(Case Western Reserve University), Fei Liu(New York State Office for People With Developmental Disabilities)
Cited by 78Open Access
Abstract
, in which cytoplasmic TDP-43 was increased. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.
Related Papers
No related papers found
Powered by citation graph analysis