Platelets subvert T cell immunity against cancer via GARP-TGFβ axis
Saleh Rachidi(Medical University of South Carolina), Alessandra Metelli(Medical University of South Carolina), Brian Riesenberg(Medical University of South Carolina), Bill X. Wu(Medical University of South Carolina), Michelle H. Nelson(Medical University of South Carolina), Caroline Wallace(Medical University of South Carolina), Chrystal M. Paulos(Medical University of South Carolina), Mark P. Rubinstein(Medical University of South Carolina), Elizabeth Garrett‐Mayer(Medical University of South Carolina), M. Hennig(Medical University of South Carolina), Daniel W. Bearden(NCCOS Hollings Marine Laboratory), Yi Yang(Medical University of South Carolina), Bei Liu(Medical University of South Carolina), Zihai Li(Medical University of South Carolina)
Cited by 320Open Access
Abstract
blunted TGFβ activity at the tumor site and potentiated protective immunity against both melanoma and colon cancer. Last, this study shows that T cell therapy of cancer can be substantially improved by concurrent treatment with readily available antiplatelet agents. We conclude that platelets constrain T cell immunity through a GARP-TGFβ axis and suggest a combination of immunotherapy and platelet inhibitors as a therapeutic strategy against cancer.
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