Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis
Thijs J. Beldman(University of Amsterdam), Max L. Senders(University of Amsterdam), Amr Alaarg(University of Twente), Carlos Pérez‐Medina(Icahn School of Medicine at Mount Sinai), Jun Tang(Memorial Sloan Kettering Cancer Center), Yiming Zhao(Icahn School of Medicine at Mount Sinai), François Fay(Icahn School of Medicine at Mount Sinai), Jacqueline Deichmöller(Ruhr University Bochum), Benjamin Born(Weizmann Institute of Science), Emilie Desclos(University of Amsterdam), Nicole N. van der Wel(University of Amsterdam), Ron A. Hoebe(University of Amsterdam), Förtüne Kohen(Weizmann Institute of Science), Elena Kartvelishvily(Weizmann Institute of Science), Michal Neeman(Weizmann Institute of Science), Thomas Reiner(Memorial Sloan Kettering Cancer Center), Claudia Calcagno(Icahn School of Medicine at Mount Sinai), Zahi A. Fayad(Icahn School of Medicine at Mount Sinai), Menno P.J. de Winther(Ludwig-Maximilians-Universität München), Esther Lutgens(Ludwig-Maximilians-Universität München), Willem J. M. Mulder(Icahn School of Medicine at Mount Sinai), Ewelina Kluza(University of Amsterdam)
Cited by 188Open Access
Abstract
Zr-HA-NPs-induced radioactivity in atherosclerotic aortas was 30% higher than in wild-type controls. PET imaging of rabbits revealed 6-fold higher standardized uptake values compared to the muscle. The plaques of HA-NP-treated mice contained 30% fewer macrophages compared to control and free HA-treated group. In conclusion, we show favorable targeting properties of HA-NPs, which can be exploited for PET imaging of atherosclerosis-associated inflammation. Furthermore, we demonstrate the anti-inflammatory effects of HA-NPs in atherosclerosis.
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