Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See(Agency for Science, Technology and Research), Charles‐Antoine Dutertre(Agency for Science, Technology and Research), Jinmiao Chen(Agency for Science, Technology and Research), Patrick Günther(University of Bonn), Naomi McGovern(Agency for Science, Technology and Research), Sergio Erdal Irac(Duke-NUS Medical School), Merry Gunawan(Newcastle University), Marc Beyer(University of Bonn), Kristian Händler(University of Bonn), Kaibo Duan(Agency for Science, Technology and Research), Hermi Sumatoh(Agency for Science, Technology and Research), Nicolas Ruffin(Inserm), Mabel Jouve(Inserm), Ester Gea‐Mallorquí(Inserm), Raoul C. M. Hennekam(University of Amsterdam), Tony Kiat Hon Lim(Singapore General Hospital), Chan Chung Yip(Health Promotion Board), Ming Wen(Duke-NUS Medical School), Benoît Malleret(Agency for Science, Technology and Research), Ivy Low(Agency for Science, Technology and Research), Nurhidaya Binte Shadan(Agency for Science, Technology and Research), Charlene Foong Shu Fen(SingHealth), Alicia Tay(Agency for Science, Technology and Research), Josephine Lum(Agency for Science, Technology and Research), Francesca Zolezzi(Agency for Science, Technology and Research), Anis Larbi(Agency for Science, Technology and Research), Michael Poidinger(Agency for Science, Technology and Research), Jerry Kok Yen Chan(Agency for Science, Technology and Research), Qingfeng Chen(Institute of Molecular and Cell Biology), Laurent Rénia(Agency for Science, Technology and Research), Muzlifah Haniffa(Newcastle University), Philippe Benaroch(Inserm), Andreas Schlitzer(Agency for Science, Technology and Research), Joachim L. Schultze(University of Bonn), Evan W. Newell(Agency for Science, Technology and Research), Florent Ginhoux(Agency for Science, Technology and Research)
Cited by 565Open Access
Abstract
Tracing development of the dendritic cell lineage Dendritic cells (DCs) are important components of the immune system that form from the bone marrow into two major cell lineages: plasmacytoid DCs and conventional DCs. See et al. applied single-cell RNA sequencing and cytometry by time-of-flight to characterize the developmental pathways of these cells. They identified blood DC precursors that shared surface markers with plasmacytoid DCs but that were functionally distinct. This unsuspected level of complexity in pre-DC populations reveals additional cell types and refines understanding of known cell types. Science , this issue p. eaag3009
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