The genetic relationship between epilepsy and hemiplegic migraine

Yiqing Huang(Guangxi Medical University), Hai Xiao(Guangxi Medical University), Xinyue Qin(Guangxi Medical University), Yuan Nong(Guangxi Medical University), Donghua Zou(Guangxi Medical University), Yuan Wu(Guangxi Medical University)
Neuropsychiatric Disease and Treatment
April 1, 2017
10.2147/ndt.s132451
Cited by 16Open Access
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Abstract

Abstract: Epilepsy and migraine are common diseases of the nervous system and share genetic and pathophysiological mechanisms. Familial hemiplegic migraine is an autosomal dominant disease. It is often used as a model of migraine. Four genes often contain one or more mutations in both epilepsy and hemiplegic migraine patients (ie, CACNA1A , ATP1A2 , SCN1A , and PRRT2 ). A better understanding of the shared genetics of epilepsy and hemiplegic migraine may reveal new strategic directions for research and treatment of both the disorders. Keywords: epilepsy, migraine, CACNA1A , ATP1A2 , SCN1A

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