Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage
Shih‐Chieh Chiang(University of Sheffield), Martin Meagher(Wellcome Centre for Mitochondrial Research), Nick Kassouf(Mount Vernon Hospital), Majid Hafezparast(University of Sussex), Peter J. McKinnon(St. Jude Children's Research Hospital), Rachel Haywood(Mount Vernon Hospital), Sherif F. El‐Khamisy(Zewail City of Science and Technology)
Cited by 59Open Access
Abstract
suggests early embryonic lethality. Together, our data show that TDP1 resolves mtPDBs, thereby regulating mitochondrial gene transcription and oxygen consumption by oxidative phosphorylation, thus conferring cellular protection against reactive oxygen species-induced damage.
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