Low expression of hexokinase-2 is associated with false-negative FDG–positron emission tomography in multiple myeloma
Leo Rasche(Myeloma UK), Edgardo Angtuaco(University of Arkansas for Medical Sciences), James E. McDonald(University of Arkansas for Medical Sciences), Amy Buros(Myeloma UK), Caleb Stein(Myeloma UK), Charlotte Pawlyn(Institute of Cancer Research), Sharmilan Thanendrarajan(Myeloma UK), Carolina Schinke(Myeloma UK), Rohan Samant(University of Arkansas for Medical Sciences), Shmuel Yaccoby(Myeloma UK), Brian A. Walker(Myeloma UK), Joshua Epstein(Myeloma UK), Maurizio Zangari(Myeloma UK), Frits van Rhee(Myeloma UK), Tobias Meißner(Avera Health), Hartmut Goldschmidt(Heidelberg University), Kari Hemminki(German Cancer Research Center), Richard S. Houlston(Institute of Cancer Research), Bart Barlogie(Myeloma UK), Faith E. Davies(Myeloma UK), Gareth J. Morgan(Myeloma UK), Niels Weinhold(Myeloma UK)
Cited by 247Open Access
Abstract
< .001) which provides a mechanistic explanation for this feature. In conclusion, we demonstrate a relevant number of patients with FDG-PET false-negative MM and a strong association between hexokinase-2 expression and this negativity: a finding which may also be relevant for clinical imaging of other hematological cancers.
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