Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Alexandra–Chloé Villani(Broad Institute), Rahul Satija(Broad Institute), Gary Reynolds(Newcastle University), Siranush Sarkizova(Broad Institute), Karthik Shekhar(Broad Institute), James Fletcher(Newcastle University), Morgane Griesbeck(Ragon Institute of MGH, MIT and Harvard), Andrew Butler(New York Genome Center), Shiwei Zheng(New York Genome Center), Suzan Lazo(Harvard University), Laura Jardine(Newcastle University), David Dixon(Newcastle University), Emily Stephenson(Newcastle University), Emil Nilsson(Olink (United States)), Ida Grundberg(Olink (United States)), David McDonald(Newcastle University), Andrew Filby(Newcastle University), Weibo Li(Broad Institute), Philip L. De Jager(Broad Institute), Orit Rozenblatt–Rosen(Broad Institute), Andrew A. Lane(Broad Institute), Muzlifah Haniffa(Royal Victoria Infirmary), Aviv Regev(Broad Institute), Nir Hacohen(Broad Institute)
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Abstract
What's in a drop of blood? Blood contains many types of cells, including many immune system components. Immune cells used to be characterized by marker-based assays, but now classification relies on the genes that cells express. Villani et al. used deep sequencing at the single-cell level and unbiased clustering to define six dendritic cell and four monocyte populations. This refined analysis has identified, among others, a previously unknown dendritic cell population that potently activates T cells. Further cell culture revealed possible differentiation progenitors within the different cell populations. Science , this issue p. eaah4573
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