Scallop genome provides insights into evolution of bilaterian karyotype and development

Shi Wang(Qingdao National Laboratory for Marine Science and Technology), Jinbo Zhang(Novogene Bioinformatics Institute), Wenqian Jiao(Ocean University of China), Ji Li(Novogene Bioinformatics Institute), Xiaogang Xun(Ocean University of China), Yan Sun(Ocean University of China), Ximing Guo(Rutgers, The State University of New Jersey), Pin Huan(Chinese Academy of Sciences), Bo Dong(Qingdao National Laboratory for Marine Science and Technology), Lingling Zhang(Ocean University of China), Xiaoli Hu(Qingdao National Laboratory for Marine Science and Technology), Xiaoqing Sun(Novogene Bioinformatics Institute), Jing Wang(Ocean University of China), Chengtian Zhao(Ocean University of China), Yangfan Wang(Ocean University of China), Dawei Wang(Novogene Bioinformatics Institute), Xiaoting Huang(Ocean University of China), Ruijia Wang(Ocean University of China), Jia Lv(Ocean University of China), Yuli Li(Ocean University of China), Zhifeng Zhang(Ocean University of China), Baozhong Liu(Chinese Academy of Sciences), Wei Lu(Ocean University of China), Yuanyuan Hui(Novogene Bioinformatics Institute), Jun Liang(Dalian University), Zunchun Zhou(Liaoning Ocean and Fisheries Research Institute), Rui Hou(Ocean University of China), Xue Li(Ocean University of China), Yunchao Liu(Novogene Bioinformatics Institute), Hengde Li(Chinese Academy of Fishery Sciences), Xianhui Ning(Ocean University of China), Yu Lin(Novogene Bioinformatics Institute), Liang Zhao(Ocean University of China), Qiang Xing(Ocean University of China), Jinzhuang Dou(Ocean University of China), Yangping Li(Ocean University of China), Junxia Mao(Ocean University of China), Haobing Guo(Ocean University of China), Huaiqian Dou(Ocean University of China), Tianqi Li(Ocean University of China), Chuang Mu(Ocean University of China), Wenkai Jiang(Novogene Bioinformatics Institute), Qiang Fu(Ocean University of China), Xiaoteng Fu(Ocean University of China), Yan Miao(Ocean University of China), Jian Liu(Novogene Bioinformatics Institute), Qian Yu(Ocean University of China), Ruojiao Li(Novogene Bioinformatics Institute), Huan Liao(Ocean University of China), Xuan Li(Ocean University of China), Yifan Kong(Ocean University of China), Zhi Jiang(Novogene Bioinformatics Institute), Daniel Chourrout(University of Bergen), Ruiqiang Li(Novogene Bioinformatics Institute), Zhenmin Bao(Qingdao National Laboratory for Marine Science and Technology)
Nature Ecology & Evolution
April 3, 2017
10.1038/s41559-017-0120
Cited by 463Open Access
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Abstract

Reconstructing the genomes of bilaterian ancestors is central to our understanding of animal evolution, where knowledge from ancient and/or slow-evolving bilaterian lineages is critical. Here we report a high-quality, chromosome-anchored reference genome for the scallop Patinopecten yessoensis, a bivalve mollusc that has a slow-evolving genome with many ancestral features. Chromosome-based macrosynteny analysis reveals a striking correspondence between the 19 scallop chromosomes and the 17 presumed ancestral bilaterian linkage groups at a level of conservation previously unseen, suggesting that the scallop may have a karyotype close to that of the bilaterian ancestor. Scallop Hox gene expression follows a new mode of subcluster temporal co-linearity that is possibly ancestral and may provide great potential in supporting diverse bilaterian body plans. Transcriptome analysis of scallop mantle eyes finds unexpected diversity in phototransduction cascades and a potentially ancient Pax2/5/8-dependent pathway for noncephalic eyes. The outstanding preservation of ancestral karyotype and developmental control makes the scallop genome a valuable resource for understanding early bilaterian evolution and biology.

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