A conserved NAD <sup>+</sup> binding pocket that regulates protein-protein interactions during aging

Jun Li(Harvard University), Michael S. Bonkowski(Harvard University), S. Moniot(University of Bayreuth), Dapeng Zhang(National Institutes of Health), Basil P. Hubbard(Harvard University), Alvin J. Y. Ling(Harvard University), Luis A. Rajman(Harvard University), Bo Qin(Mayo Clinic), Zhenkun Lou(Mayo Clinic), Vera Gorbunova(University of Rochester), L. Aravind(National Institutes of Health), Clemens Steegborn(University of Bayreuth), David Sinclair(Harvard University)
Science
March 23, 2017
10.1126/science.aad8242
Cited by 183Open Access
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Abstract

directly regulates protein-protein interactions, the modulation of which may protect against cancer, radiation, and aging.

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