A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice

Tyson R. Chiaro(University of Utah), Ray Soto(University of Utah), W. Zac Stephens(University of Utah), Jason L. Kubinak(University of Utah), Charisse Petersen(University of Utah), Lasha Gogokhia(University of Utah), Rickesha Bell(University of Utah), Julio C. Delgado(University of Utah), James E. Cox(University of Utah), Warren P. Voth(University of Utah), Jessica C. S. Brown(University of Utah), David J. Stillman(University of Utah), Ryan M. O’Connell(University of Utah), Anne E. Tebo(University of Utah), June L. Round(University of Utah)
Science Translational Medicine
March 8, 2017
Cited by 224Open Access
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Abstract

in mice. In addition, we found a positive correlation between elevated uric acid and anti-yeast antibodies in human sera. Thus, yeast in the gut may be able to potentiate metabolite production that negatively affects the course of inflammatory bowel disease.


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