An optimized IFN-γ ELISpot assay for the sensitive and standardized monitoring of CMV protein-reactive effector cells of cell-mediated immunity

Sascha Barabas(Lophius Biosciences (Germany)), Theresa Spindler(Lophius Biosciences (Germany)), Richard Kiener(Institute of Medical Microbiology and Hygiene), Charlotte Tonar(Lophius Biosciences (Germany)), Tamara Lugner(Lophius Biosciences (Germany)), Julia Batzilla(Lophius Biosciences (Germany)), Hanna Bendfeldt(Lophius Biosciences (Germany)), Anne Rascle(Lophius Biosciences (Germany)), Benedikt Asbach(Institute of Medical Microbiology and Hygiene), Ralf Wagner(Institute of Medical Microbiology and Hygiene), Ludwig Deml(Lophius Biosciences (Germany))
BMC Immunology
March 7, 2017
10.1186/s12865-017-0195-y
Cited by 68Open Access
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Abstract

Background: In healthy individuals, Cytomegalovirus (CMV) infection is efficiently controlled by CMV-specific cellmediated immunity (CMI). Functional impairment of CMI in immunocompromized individuals however can lead to uncontrolled CMV replication and severe clinical complications. Close monitoring of CMV-specific CMI is therefore clinically relevant and might allow a reliable prognosis of CMV disease as well as assist personalized therapeutic decisions.

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