Combining the advantages of CellSearch and CellCelector enables the characterization of circulating tumor cells
Martín Neumann(Heinrich Heine University Düsseldorf), S Schömer(Heinrich Heine University Düsseldorf), Y Decker(Heinrich Heine University Düsseldorf), H Schneck(Heinrich Heine University Düsseldorf), Rodrigo Xavier das Neves(Heinrich Heine University Düsseldorf), Luis Brandi(Heinrich Heine University Düsseldorf), N Stoecklein(Heinrich Heine University Düsseldorf), Tanja Fehm(Heinrich Heine University Düsseldorf), F Meier-Stiegen(Heinrich Heine University Düsseldorf), Hans Neubauer(Heinrich Heine University Düsseldorf), Dieter Niederacher(Heinrich Heine University Düsseldorf)
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Abstract
Circulating tumor cells (CTC) are rare cells and dissociated successfully from the primary tumor into the blood stream. Only a small proportion is capable to extravasate and form metastases. However, the presence of CTCs is associated with increased risk to develop metastases and therefore a short survival. Understanding the heterologous CTC biology enables the choice of the optimal therapy and improves the prognosis. For this, detection and isolation of CTCs is necessary. Here we show a workflow to characterize CTCs by combining the advantages of both the CellSearch®- and CellCelector™-System.
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