CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer

Malachi Griffith(James S. McDonnell Foundation), Nicholas C. Spies(James S. McDonnell Foundation), Kilannin Krysiak(James S. McDonnell Foundation), Joshua F. McMichael(James S. McDonnell Foundation), Adam Coffman(James S. McDonnell Foundation), Arpad Danos(James S. McDonnell Foundation), Benjamin J. Ainscough(James S. McDonnell Foundation), Cody A. Ramirez(James S. McDonnell Foundation), Damian Rieke(Charité - Universitätsmedizin Berlin), Lynzey Kujan(James S. McDonnell Foundation), Erica K. Barnell(James S. McDonnell Foundation), Alex H. Wagner(James S. McDonnell Foundation), Zachary L. Skidmore(James S. McDonnell Foundation), Amber Z. Wollam(James S. McDonnell Foundation), Connor J. Liu(James S. McDonnell Foundation), Martin Jones(Canada's Michael Smith Genome Sciences Centre), Rachel L Bilski(James S. McDonnell Foundation), Robert Lesurf(James S. McDonnell Foundation), Yan-Yang Feng(James S. McDonnell Foundation), Nakul M. Shah(James S. McDonnell Foundation), Melika Bonakdar(Canada's Michael Smith Genome Sciences Centre), Lee Trani(James S. McDonnell Foundation), Matthew K. Matlock(James S. McDonnell Foundation), Avinash Ramu(James S. McDonnell Foundation), Katie M. Campbell(James S. McDonnell Foundation), Gregory C. Spies(James S. McDonnell Foundation), Aaron Graubert(James S. McDonnell Foundation), Karthik Gangavarapu(Scripps Research Institute), James M. Eldred(James S. McDonnell Foundation), David E. Larson(James S. McDonnell Foundation), Jason Walker(James S. McDonnell Foundation), Benjamin M. Good(Scripps Research Institute), Chunlei Wu(Scripps Research Institute), Andrew I. Su(Scripps Research Institute), Rodrigo Dienstmann(Vall d'Hebron Hospital Universitari), Adam A. Margolin(Oregon Health & Science University), David Tamborero(Institute for Research in Biomedicine), Núria López-Bigas(Institute for Research in Biomedicine), Steven J.M. Jones(Canada's Michael Smith Genome Sciences Centre), Ron Bose(Washington University in St. Louis), David H. Spencer(James S. McDonnell Foundation), Lukas D. Wartman(James S. McDonnell Foundation), Richard K. Wilson(James S. McDonnell Foundation), Elaine R. Mardis(James S. McDonnell Foundation), Obi L. Griffith(James S. McDonnell Foundation)
Nature Genetics
January 31, 2017
Cited by 672Open Access
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Abstract

CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types. CIViC is committed to open-source code, open-access content, public application programming interfaces (APIs) and provenance of supporting evidence to allow for the transparent creation of current and accurate variant interpretations for use in cancer precision medicine.


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