Circular RNAs in human cancer

Yumin Wang(Central South University), Yongzhen Mo(Xiangya Hospital Central South University), Zhaojian Gong(Central South University), Xiang Yang(Central South University), Mo Yang(Central South University), Shanshan Zhang(Xiangya Hospital Central South University), Fang Xiong(Xiangya Hospital Central South University), Bo Xiang(Third Xiangya Hospital), Ming Zhou(Hunan Cancer Hospital), Qianjin Liao(Central South University), Wenling Zhang(Central South University), Xiayu Li(Third Xiangya Hospital), Xiaoling Li(Third Xiangya Hospital), Yong Li(Cleveland Clinic Lerner College of Medicine), Guiyuan Li(Xiangya Hospital Central South University), Zhaoyang Zeng(Xiangya Hospital Central South University), Wei Xiong(Third Xiangya Hospital)
Molecular Cancer
January 31, 2017
10.1186/s12943-017-0598-7
Cited by 527Open Access
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Abstract

CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique structure, they are more stable than linear RNAs. CircRNAs play important roles in the carcinogenesis of cancer. The expression of circRNAs is correlated with patients' clinical characteristics, and circRNAs play a vital role in many aspects of malignant phenotypes, including cell cycle, apoptosis, vascularization, and invasion; metastasis as a RNA sponge, binding to RBP; or translation. Therefore, it is meaningful to further study the mechanism of interactions between circRNAs and tumors. The role of circRNAs as molecular markers or potential targets will provide promising application perspectives, such as early tumor diagnosis, therapeutic evaluation, prognosis prediction, and even gene therapy for tumors.

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