The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

Yupeng He; Sujatha Selvaraju; Michael L. Curtin; Clarissa G. Jakob; Haizhong Zhu; Kenneth M. Comess; Bailin Shaw; Juliana The; Evelyne Lima‐Fernandes; Magdalena M. Szewczyk; Dong Cheng; Kelly L. Klinge; Huan‐Qiu Li; Marina Pliushchev; Mikkel A. Algire; David Maag; Jun Guo; Justin Dietrich; Sanjay C. Panchal; Andrew M. Petros; Ramzi F. Sweis; Maricel Torrent; L. Bigelow; Guillermo Senisterra; Fengling Li; Steven Kennedy; Qin Wu; Donald J. Osterling; David Lindley; Wenqing Gao; Scott Galasinski; Dalia Baršytė-Lovejoy; Masoud Vedadi; F. Gregory Buchanan; C.H. Arrowsmith; Gary G. Chiang; Chaohong Sun; William N. Pappano

doi:10.1038/nchembio.2306

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

Yupeng He(AbbVie (United States)), Sujatha Selvaraju(AbbVie (United States)), Michael L. Curtin(AbbVie (United States)), Clarissa G. Jakob(AbbVie (United States)), Haizhong Zhu(AbbVie (United States)), Kenneth M. Comess(AbbVie (United States)), Bailin Shaw(AbbVie (United States)), Juliana The(University of Toronto), Evelyne Lima‐Fernandes(University of Toronto), Magdalena M. Szewczyk(University of Toronto), Dong Cheng(AbbVie (United States)), Kelly L. Klinge(AbbVie (United States)), Huan‐Qiu Li(AbbVie (United States)), Marina Pliushchev(AbbVie (United States)), Mikkel A. Algire(AbbVie (United States)), David Maag(AbbVie (United States)), Jun Guo(AbbVie (United States)), Justin Dietrich(AbbVie (United States)), Sanjay C. Panchal(AbbVie (United States)), Andrew M. Petros(AbbVie (United States)), Ramzi F. Sweis(AbbVie (United States)), Maricel Torrent(AbbVie (United States)), L. Bigelow(AbbVie (United States)), Guillermo Senisterra(University of Toronto), Fengling Li(University of Toronto), Steven Kennedy(University of Toronto), Qin Wu(University of Toronto), Donald J. Osterling(AbbVie (United States)), David Lindley(AbbVie (United States)), Wenqing Gao(AbbVie (United States)), Scott Galasinski(AbbVie (United States)), Dalia Baršytė-Lovejoy(University of Toronto), Masoud Vedadi(University of Toronto), F. Gregory Buchanan(AbbVie (United States)), C.H. Arrowsmith(University of Toronto), Gary G. Chiang(AbbVie (United States)), Chaohong Sun(AbbVie (United States)), William N. Pappano(AbbVie (United States))

Nature Chemical Biology

January 30, 2017

10.1038/nchembio.2306

Cited by 233Open Access

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