Mature CD10+ and immature CD10− neutrophils present in G-CSF–treated donors display opposite effects on T cells
Olivia Marini(General Department of Preventive Medicine), Sara Costa(General Department of Preventive Medicine), Dalila Bevilacqua(General Department of Preventive Medicine), Federica Calzetti(General Department of Preventive Medicine), Nicola Tamassia(General Department of Preventive Medicine), Cecilia Spina(National Marrow Donor Program), D. De Sabata(National Marrow Donor Program), Elisa Tinazzi, Claudio Lunardi, Maria Teresa Scupoli, Chiara Cavallini, Elisa Zoratti(University of Verona), Ilaria Tinazzi(Ospedale Sacro Cuore Don Calabria), Antonio Marchetta(Ospedale Sacro Cuore Don Calabria), Aurora Vassanelli(University of Verona), Maurizio Cantini(University of Verona), Giorgio Gandini(University of Verona), Andrea Ruzzenente(University of Verona), Alfredo Guglielmi(University of Verona), Francesco Missale(University of Brescia), William Vermi(University of Brescia), Cristina Tecchio(National Marrow Donor Program), Marco A. Cassatella(General Department of Preventive Medicine), Patrizia Scapini(General Department of Preventive Medicine)
Cited by 342Open Access
Abstract
neutrophils, also present in GDs, display an immature morphology, promote T-cell survival, and enhance proliferation and IFNγ production by T cells. Altogether, our findings uncover that in GDs, circulating mature and immature neutrophils, distinguished by their differential CD10 expression, exert opposite immunoregulatory properties. Therefore, CD10 might be used as a phenotypic marker discriminating mature neutrophils from immature neutrophil populations present in patients with acute or chronic inflammatory conditions, as well as facilitating their isolation, to better define their specific immunoregulatory properties.
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