Regeneration of fat cells from myofibroblasts during wound healing

Maksim V. Plikus(University of California, Irvine), Christian F. Guerrero‐Juarez(University of California, Irvine), Mayumi Ito(New York University), Yun Rose Li(University of Pennsylvania), Priya H. Dedhia(Cancer Research Institute), Ying Zheng(University of Pennsylvania), Mengle Shao(The University of Texas Southwestern Medical Center), Denise Gay(Inserm), Raúl Ramos(University of California, Irvine), Tsai‐Ching Hsi(University of California, Irvine), Ji Won Oh(University of California, Irvine), Xiaojie Wang(University of California, Irvine), Amanda Ramirez(University of California, Irvine), Sara E. Konopelski(University of California, Irvine), Arijh Elzein(University of California, Irvine), Anne Wang(University of Pennsylvania), Rarinthip June Supapannachart(University of Pennsylvania), Hye-Lim Lee(University of California, Irvine), Chae Ho Lim(New York University), Arben Nace(University of Pennsylvania), Amy Guo(University of Pennsylvania), Elsa Treffeisen(University of Pennsylvania), Thomas Andl(University of Central Florida), Ricardo N. Ramírez(University of California, Irvine), Rabi Murad(University of California, Irvine), Stefan Offermanns(Max Planck Institute for Heart and Lung Research), Daniel METZGER(Centre National de la Recherche Scientifique), Pierre Chambon(Centre National de la Recherche Scientifique), Alan D. Widgerow(University of California, Irvine), Tai‐Lan Tuan(Children's Hospital of Los Angeles), A Mortazavi(University of California, Irvine), Rana K. Gupta(The University of Texas Southwestern Medical Center), Bruce A. Hamilton(La Jolla Institute For Molecular Medicine), Sarah E. Millar(University of Pennsylvania), Patrick Seale(University of Pennsylvania), Warren S. Pear(Cancer Research Institute), Mitchell A. Lazar(University of Pennsylvania), George Cotsarelis(University of Pennsylvania)
Science
January 5, 2017
10.1126/science.aai8792
Cited by 572Open Access
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Abstract

Hair follicles: Secret to prevent scars? Although some animals easily regenerate limbs and heal broken flesh, mammals are generally not so gifted. Wounding can leave scars, which are characterized by a lack of hair follicles and cutaneous fat. Plikus et al. now show that hair follicles in both mice and humans can convert myofibroblasts, the predominant dermal cell in a wound, into adipocytes (see the Perspective by Chan and Longaker). The hair follicles activated the bone morphogenetic protein (BMP) signaling pathway and adipocyte transcription factors in the myofibroblast. Thus, it may be possible to reduce scar formation after wounding by adding BMP. Science , this issue p. 748 ; see also p. 693

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