The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in Compliance With Trabecular Cutting

David L. Halaney(The University of Texas at San Antonio Health Science Center), Arnav Sanyal(The University of Texas at San Antonio), Navid A. Nafissi(The University of Texas at San Antonio Health Science Center), Daniel Escobedo(The University of Texas at San Antonio Health Science Center), Martin Goros(The University of Texas at San Antonio Health Science Center), Joel Michalek(The University of Texas at San Antonio Health Science Center), Pedro Acevedo(University of Applied and Environmental Sciences), William Pérez(Universidad de la República de Uruguay), G. Patricia Escobar(The University of Texas at San Antonio Health Science Center), Marc D. Feldman(The University of Texas at San Antonio Health Science Center), Hai‐Chao Han(The University of Texas at San Antonio)
Journal of Biomechanical Engineering
December 26, 2016
10.1115/1.4035585
Cited by 26Open Access
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Abstract

The role of trabeculae carneae in modulating left ventricular (LV) diastolic compliance remains unclear. The objective of this study was to determine the contribution of trabeculae carneae to the LV diastolic compliance. LV pressure-volume compliance curves were measured in six human heart explants from patients with LV hypertrophy at baseline and following trabecular cutting. The effect of trabecular cutting was also analyzed with finite-element model (FEM) simulations. Our results demonstrated that LV compliance improved after trabecular cutting (p < 0.001). Finite-element simulations further demonstrated that stiffer trabeculae reduce LV compliance further, and that the presence of trabeculae reduced the wall stress in the apex. In conclusion, we demonstrate that integrity of the LV and trabeculae is important to maintain LV stiffness and loss in trabeculae leads to more LV compliance.

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