p53 pathway is involved in cell competition during mouse embryogenesis
Guoxin Zhang(Model Animal Research Center), Yinyin Xie(Model Animal Research Center), Ying Zhou(Model Animal Research Center), Cong Xiang(Model Animal Research Center), Lai Chen(Jiangxi University of Traditional Chinese Medicine), Chenxi Zhang(Model Animal Research Center), Xiaoshuang Hou(Model Animal Research Center), Jiong Chen(Model Animal Research Center), Hui Zong(University of Virginia), Geng Liu(Model Animal Research Center)
Cited by 74Open Access
Abstract
cells exhibited a growth disadvantage and were outcompeted during development in genetic mosaic embryos that contained wild-type cells. Further study indicated the out-competition phenotype was dependent on the levels of p53. These observations revealed that cells with mild p53 activation were less fit and exhibited altered fates in a heterotypic environment, resembling the cell competition phenomenon first uncovered in Drosophila By marking unfit cells for elimination, p53 may exert its physiological role to ensure organ and animal fitness.
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