Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults
Nitin Jain(The University of Texas MD Anderson Cancer Center), Kathryn G. Roberts(St. Jude Children's Research Hospital), Elias Jabbour(The University of Texas MD Anderson Cancer Center), Keyur P. Patel, Agda Karina Eterovic(Center for Personalized Cancer Treatment), Ken Chen(Center for Personalized Cancer Treatment), Patrick A. Zweidler‐McKay(The University of Texas MD Anderson Cancer Center), Xinyan Lu, Gloria L. Fawcett(Center for Personalized Cancer Treatment), Sa A. Wang, Sergej Konoplev, Richard C. Harvey(University of New Mexico), I‐Ming Chen(University of New Mexico), Debbie Payne-Turner(St. Jude Children's Research Hospital), Marcus Valentine(St. Jude Children's Research Hospital), Deborah A. Thomas(The University of Texas MD Anderson Cancer Center), Guillermo Garcia‐Manero(The University of Texas MD Anderson Cancer Center), Farhad Ravandi(The University of Texas MD Anderson Cancer Center), Jörge E. Cortes(The University of Texas MD Anderson Cancer Center), Steven M. Kornblau(The University of Texas MD Anderson Cancer Center), Susan O’Brien(University of California, Irvine Medical Center), Sherry Pierce(The University of Texas MD Anderson Cancer Center), Jeffrey L. Jorgensen, Kenna Shaw(Center for Personalized Cancer Treatment), Cheryl L. Willman(University of New Mexico), Charles G. Mullighan(St. Jude Children's Research Hospital), Hagop M. Kantarjian(The University of Texas MD Anderson Cancer Center), Marina Konopleva(The University of Texas MD Anderson Cancer Center)
Cited by 385Open Access
Abstract
Key Points Approximately 20% to 25% of adults with B-ALL have Ph-like ALL with increased frequency of Ph-like ALL in adults with Hispanic ethnicity. Adult patients with CRLF2+ ALL have poor long-term outcomes; novel strategies are needed to improve the outcomes.
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