Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism

Jean‐Charles Lambert; Florie Demiautte; Fanny Eysert; Elaine R. Peskind; John Q. Trojanowski; Kaj Blennow; Adrien Herlédan; Charlotte Bauer; Philippe Amouyel; Virginie Pottiez; Carlos Cruchaga; Vivianna M. Van Deerlin; Ronald C. Petersen; Amandine Flaig; Florence Leroux; Gaspard Deloison; Pierre Dourlen; Virginia Man-Yee Lee; Abhay Moghekar; Julien Chapuis; Richard M. O’Brien; Priscille Brodin; Henrik Zetterberg; Ok‐Ryul Song; Lennart Minthon; Tiago Mendes; Benoît Déprez; Frédéric Checler; Shruti Desai; Alexandre Vandeputte; Alison Goate; Leslie M. Shaw; Gerard D. Schellenberg; John Kauwe; Nicolas Malmanche; Benjamin Grenier‐Boley; Anne‐Marie Ayral; Marilyn Albert

doi:10.1007/s00401-016-1652-z

Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism

Jean‐Charles Lambert(Inserm), Florie Demiautte(Inserm), Fanny Eysert(Centre National de la Recherche Scientifique), Elaine R. Peskind(Inserm), John Q. Trojanowski(California University of Pennsylvania), Kaj Blennow(Sahlgrenska University Hospital), Adrien Herlédan(Inserm), Charlotte Bauer(Centre National de la Recherche Scientifique), Philippe Amouyel(Institut Pasteur de Lille), Virginie Pottiez(Centre National de la Recherche Scientifique), Carlos Cruchaga(Washington University in St. Louis), Vivianna M. Van Deerlin(University of Pennsylvania), Ronald C. Petersen(Mayo Clinic), Amandine Flaig(Inserm), Florence Leroux(Inserm), Gaspard Deloison(Centre National de la Recherche Scientifique), Pierre Dourlen(Inserm), Virginia Man-Yee Lee(University of Pennsylvania), Abhay Moghekar(Johns Hopkins University), Julien Chapuis(Inserm), Richard M. O’Brien(Vanderbilt University), Priscille Brodin(Centre National de la Recherche Scientifique), Henrik Zetterberg(Queen Mary University of London), Ok‐Ryul Song(Centre National de la Recherche Scientifique), Lennart Minthon(Lund University), Tiago Mendes(Inserm), Benoît Déprez(Centre National de la Recherche Scientifique), Frédéric Checler(Centre National de la Recherche Scientifique), Shruti Desai(Inserm), Alexandre Vandeputte(Centre National de la Recherche Scientifique), Alison Goate(Icahn School of Medicine at Mount Sinai), Leslie M. Shaw(University of Pennsylvania), Gerard D. Schellenberg(University of Pennsylvania), John Kauwe(Brigham Young University), Nicolas Malmanche(Universidade do Porto), Benjamin Grenier‐Boley(University of Bonn), Anne‐Marie Ayral(Inserm), Marilyn Albert(Johns Hopkins Medicine)

Acta Neuropathologica

December 8, 2016

10.1007/s00401-016-1652-z

Cited by 78

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