Open Targets: a platform for therapeutic target identification and validation

Gautier Koscielny(Age UK), Peter An(Biogen (United States)), Denise Carvalho‐Silva(European Bioinformatics Institute), Jennifer A. Cham(European Bioinformatics Institute), Luca Fumis(European Bioinformatics Institute), Rippa Gasparyan(Biogen (United States)), Samiul Hasan(Age UK), Nikiforos Karamanis(European Bioinformatics Institute), Michael E. Maguire(European Bioinformatics Institute), Eliseo Papa(Biogen (United States)), Andrea Pierleoni(European Bioinformatics Institute), Miguel Pignatelli(European Bioinformatics Institute), Theo Platt(Biogen (United States)), Francis Rowland(European Bioinformatics Institute), Priyanka Wankar(Biogen (United States)), A. Patrícia Bento(European Bioinformatics Institute), Tony Burdett(European Bioinformatics Institute), Antonio Fabregat(European Bioinformatics Institute), Simon Forbes(Wellcome Sanger Institute), Anna Gaulton(European Bioinformatics Institute), Cristina González(European Bioinformatics Institute), Henning Hermjakob(European Bioinformatics Institute), Anne Hersey(European Bioinformatics Institute), Steven Jupe(European Bioinformatics Institute), Şenay Kafkas(European Bioinformatics Institute), Maria Keays(European Bioinformatics Institute), Catherine Leroy(European Bioinformatics Institute), Francisco-Javier Lopez(European Bioinformatics Institute), María Paula Magariños(European Bioinformatics Institute), James Malone(European Bioinformatics Institute), Johanna McEntyre(European Bioinformatics Institute), Alfonso Muñoz-Pomer Fuentes(European Bioinformatics Institute), Claire O’Donovan(European Bioinformatics Institute), Irene Papatheodorou(European Bioinformatics Institute), Helen Parkinson(European Bioinformatics Institute), Barbara P. Palka(European Bioinformatics Institute), Justin Paschall(European Bioinformatics Institute), Robert Petryszak(European Bioinformatics Institute), Ploy N. Pratanwanich(European Bioinformatics Institute), Sirarat Sarntivijal(European Bioinformatics Institute), Gary Saunders(European Bioinformatics Institute), Konstantinos Sidiropoulos(European Bioinformatics Institute), Thomas B. Smith(European Bioinformatics Institute), Zbysław Sońdka(Wellcome Sanger Institute), Oliver Stegle(European Bioinformatics Institute), Amy Tang(European Bioinformatics Institute), E. B. Turner(European Bioinformatics Institute), Brendan Vaughan(European Bioinformatics Institute), Olga Vrousgou(European Bioinformatics Institute), Xavier Watkins(European Bioinformatics Institute), María Martin(European Bioinformatics Institute), Philippe Sanséau(Age UK), Jessica Vamathevan(European Bioinformatics Institute), Ewan Birney(European Bioinformatics Institute), Jeffrey C. Barrett(European Bioinformatics Institute), Ian Dunham(European Bioinformatics Institute)
Nucleic Acids Research
November 3, 2016
10.1093/nar/gkw1055
Cited by 526Open Access
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Abstract

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org.

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