Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
Zachary Steinhart(University of Toronto), Zvezdan Pavlovic(University of Toronto), Megha Chandrashekhar(University of Toronto), Traver Hart(University of Toronto), Xiaowei Wang(University of Toronto), Xiaoyu Zhang(University of Toronto), Mélanie Robitaille(University of Toronto), Kevin R. Brown(University of Toronto), Sridevi Jaksani(Hubrecht Institute for Developmental Biology and Stem Cell Research), René Overmeer(Hubrecht Institute for Developmental Biology and Stem Cell Research), Sylvia F. Boj(Hubrecht Institute for Developmental Biology and Stem Cell Research), Jarrett Adams(University of Toronto), James Pan(University of Toronto), Hans Clevers(Hubrecht Institute for Developmental Biology and Stem Cell Research), Sachdev S. Sidhu(University of Toronto), Jason Moffat(Canadian Institute for Advanced Research), Stéphane Angers(University of Toronto)
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