Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
Yingying Wang(University of Arkansas for Medical Sciences), Jianhui Chang(University of Arkansas for Medical Sciences), Xingui Liu(University of Arkansas for Medical Sciences), Xuan Zhang(Winthrop Rockefeller Foundation), Suping Zhang(Winthrop Rockefeller Foundation), Xin Zhang(Winthrop Rockefeller Foundation), Daohong Zhou(Winthrop Rockefeller Foundation), Guangrong Zheng(University of Arkansas for Medical Sciences)
Cited by 266Open Access
Abstract
. PL killed SCs by inducing apoptosis, and this process did not require the induction of reactive oxygen species. In addition, we found that PL synergistically killed SCs in combination with ABT-263, and initial structural modifications to PL identified analogs with improved potency and/or selectivity in inducing SC death. Overall, our studies demonstrate that PL is a novel lead for developing senolytic agents.
Related Papers
No related papers found
Powered by citation graph analysis