Radical (Phenylsulfonyl)difluoromethylation of Isocyanides with PhSO<sub>2</sub>CF<sub>2</sub>H under Transition-Metal-Free Conditions

Pan Xiao(Chinese Academy of Sciences), Jian Rong(Chinese Academy of Sciences), Chuanfa Ni(Chinese Academy of Sciences), Junkai Guo(Chinese Academy of Sciences), Xinjin Li(Chinese Academy of Sciences), Dingben Chen(Chinese Academy of Sciences), Jinbo Hu(Chinese Academy of Sciences)
Organic Letters
November 9, 2016
10.1021/acs.orglett.6b03013
Cited by 74

Abstract

An atom-economical method for radical (phenylsulfonyl)difluoromethylation of isocyanides with PhSO2CF2H under transition-metal-free conditions has been developed. A PhSO2CF2 radical is generated through the oxidation of PhSO2CF2– after the deprotonation of PhSO2CF2H in one pot. The reaction exhibits excellent functional-group tolerance and the resulting products can be further modified with the removal of a PhSO2 group to give other CF2-containing compounds.

Related Papers

No related papers found

Powered by citation graph analysis