Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core
Mei Han(Ocean University of China), Meiyu Geng(Shanghai Institute of Materia Medica), Ao Zhang(Chinese Academy of Sciences), Xing Li(Shaanxi Normal University), Jing Ai(Baoshan College), Yi Su(Fourth Hospital of Inner Mongolia), Zilan Song(Chinese Academy of Sciences), Yinchun Ji(Chinese Academy of Sciences), Xi‐Sheng Wang(University of Science and Technology of China)
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