Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression
Shang-Jui Wang(Cancer Genetics (United States)), Dawei Li(Cancer Genetics (United States)), Yang Ou(Cancer Genetics (United States)), Le Jiang(Cancer Genetics (United States)), Yue Chen(University of Chicago), Yingming Zhao(University of Chicago), Wei Gu(Cancer Genetics (United States))
Cited by 463Open Access
Abstract
is still capable of inducing the p53-Mdm2 feedback loop, but p53-dependent ferroptotic responses are markedly abrogated. Together, these data indicate the critical role of p53 acetylation in ferroptotic responses and its remaining tumor suppression activity.
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