Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus

Chin‐Yuan Chang(Scripps Research Institute), Ben Shen(Brunel University of London), Kemin Tan(Argonne National Laboratory), C.A. Bingman(University of Wisconsin–Madison), Jeffrey D. Rudolf(University of Florida), Weijun Xu(Rice University), Ragothaman M. Yennamalli(Jaypee University of Information Technology), Jeremy R. Lohman(Scripps Research Institute), G. Babnigg(Argonne National Laboratory), Xiaohui Yan(Scripps Research Institute), L. Bigelow(AbbVie (United States)), Hongnan Cao(Rice University), Ming Ma(Hunan Normal University), A. Joachimiak(Argonne National Laboratory)

Biochemistry

August 25, 2016

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Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in <i>Streptomyces globisporus</i>