Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice
Yasuyuki Saito(University of Zurich), Jana M. Ellegast(University of Zurich), Anahita Rafiei(University of Zurich), Yuanbin Song(Yale University), Daniel Kull(Helmholtz Zentrum München), Mathias Heikenwälder(German Cancer Research Center), Anthony Rongvaux(Yale University), Stephanie Halene(Yale Cancer Center), Richard A. Flavell(Howard Hughes Medical Institute), Markus G. Manz(University of Zurich)
Cited by 84Open Access
Abstract
recipients. Furthermore, newborn transplanted MSTRG/MISTRG mice supported higher engraftment levels of human phenotypically defined HSPCs in BM, T cells in the thymus, and myeloid cells in nonhematopoietic organs such as liver, lung, colon, and skin, approximating the levels in the human system. Similar results were obtained in adult recipient mice. Thus, human cytokine knock-in mice might open new avenues for personalized studies of human pathophysiology of the hematopoietic and immune system in vivo.
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