Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients
Thomas Condamine(The Wistar Institute), George A. Dominguez(The Wistar Institute), Je‐In Youn(The Wistar Institute), Andrew V. Kossenkov(The Wistar Institute), Sridevi Mony(The Wistar Institute), Kevin Alicea-Torres(The Wistar Institute), Evgenii N. Tcyganov(The Wistar Institute), Ayumi Hashimoto(The Wistar Institute), Yulia Nefedova(The Wistar Institute), Cindy Lin(The Wistar Institute), Simona Partlová(The Wistar Institute), Alfred L. Garfall(University of Pennsylvania), Dan T. Vogl(University of Pennsylvania), Xiaowei Xu(University of Pennsylvania), Stella C. Knight(Imperial College London), George Malietzis(St Mark's Hospital), Gui Han Lee(St Mark's Hospital), Evgeniy Eruslanov(University of Pennsylvania), Steven Μ. Albelda(University of Pennsylvania), Xianwei Wang(University of Arkansas for Medical Sciences), Jawahar L. Mehta(University of Arkansas for Medical Sciences), Meenakshi Bewtra(University of Pennsylvania), Anil K. Rustgi(University of Pennsylvania), Neil Hockstein(Christiana Care Health System), Robert Witt(Christiana Care Health System), Gregory A. Masters(Christiana Care Health System), Brian Nam(Christiana Care Health System), Denis A. Smirnov(Johnson & Johnson (United States)), Manuel A. Sepúlveda(Johnson & Johnson (United States)), Dmitry I. Gabrilovich(The Wistar Institute)
Cited by 793
Abstract
neutrophils had gene signature, potent immune suppressive activity, up-regulation of ER stress, and other biochemical characteristics of PMN-MDSC. Moreover, induction of ER stress in neutrophils from healthy donors up-regulated LOX-1 expression and converted these cells to suppressive PMN-MDSC. Thus, we identified a specific marker of human PMN-MDSC associated with ER stress and lipid metabolism, which provides new insight to the biology and potential therapeutic targeting of these cells.
Related Papers
No related papers found
Powered by citation graph analysis