Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

PARALS Registry; Wouter van Rheenen; SLALOM Group; SLAP Registry; NNIPPS Study Group; Aleksey Shatunov; Annelot M. Dekker; Russell L. McLaughlin; Frank P. Diekstra; Sara L. Pulit; Rick A. A. van der Spek; Urmo Võsa; Simone de Jong; Matthew R. Robinson; Jian Yang; Isabella Fogh; Perry Tc van Doormaal; Gijs Tazelaar; Max Koppers; Anna M. Blokhuis; William Sproviero; Ashley R Jones; Kevin P. Kenna; Kristel R. van Eijk; Oliver Harschnitz; Raymond D. Schellevis; William J. Brands; Jelena Medic; Androniki Menelaou; Alice Vajda; Nicola Ticozzi; Kuang Lin; Boris Rogelj; Katarina Vrabec; Metka Ravnik‐Glavač; Blaž Koritnik; Janez Zidar; Lea Leonardis; Leja Dolenc Grošelj; Stéphanie Millecamps; François Salachas; Vincent Meininger; Mamede de Carvalho; Susana Pinto; Jesús S. Mora; Ricardo Rojas-García; Meraida Polak; Siddharthan Chandran; Shuna Colville; Robert Swingler; Karen Morrison; Pamela J. Shaw; John Hardy; Richard W. Orrell; Alan Pittman; Katie Sidle; Pietro Fratta; Andrea Malaspina; Simon Topp; Susanne Petri; Susanne Abdulla; Carsten Drepper; Michael Sendtner; Thomas Meyer; Roel A. Ophoff; Kim A. Staats; Martina Wiedau‐Pazos; Catherine Lomen‐Hoerth; Vivianna M. Van Deerlin; John Q. Trojanowski; Lauren Elman; Leo McCluskey; A. Nazlı Başak; Ceren Tunca; Hamid Hamzeiy; Yeşim Parman; Thomas Meitinger; Peter Lichtner; Milena Radivojkov‐Blagojevic; Christian Andrés; Cindy Maurel; Gilbert Bensimon; G. Bernhard Landwehrmeyer; Alexis Brice; Christine Payan; Safaa Saker-Delye; Alexandra Dürr; Nicholas Wood; Lukas Tittmann; Wolfgang Lieb; André Franke; Marcella Rietschel; Sven Cichon; Markus M. Nöthen; Philippe Amouyel; Christophe Tzourio; Jean‐François Dartigues; André G. Uitterlinden; Fernando Rivadeneira; Karol Estrada; Albert Hofman; Charles Curtis; Hylke M. Blauw; Anneke J. van der Kooi; Marianne de Visser; An Goris; Markus Weber; Christopher E. Shaw; Bradley Smith; Orietta Pansarasa; Cristina Cereda; Roberto Del Bo; Giacomo P. Comi; Sandra D’Alfonso; Cinzia Bertolin; Gianni Sorarú; Letizia Mazzini; Viviana Pensato; Cinzia Gellera; Cinzia Tiloca; Antonia Ratti; Andrea Calvo; Cristina Moglia; Maura Brunetti; Simona Arcuti; Rosa Capozzo; Chiara Zecca; Christian Lunetta; Silvana Penco; Nilo Riva; Alessandro Padovani; Massimiliano Filosto; Bernard Müller; Robbert Jan Stuit; Ian P. Blair; Katharine Zhang; Emily P. McCann; Jennifer A. Fifita; Garth A. Nicholson; Dominic B. Rowe; Roger Pamphlett; Matthew C. Kiernan; Julian Großkreutz; Otto W. Witte; Thomas Ringer; Tino Prell; Beatrice Stubendorff; Ingo Kurth; Christian A. Hübner; P. Nigel Leigh; Federico Casale; Adriano Chiò; Ettore Beghi; Elisabetta Pupillo; Rosanna Tortelli; Giancarlo Logroscino; John Powell; Albert C. Ludolph; Jochen H. Weishaupt; Wim Robberecht; Philip Van Damme; Lude Franke; Tune H. Pers; Robert H. Brown; Jonathan D. Glass; John E. Landers; Orla Hardiman; Peter M. Andersen; Philippe Corcia; Patrick Vourc’h; Vincenzo Silani; Naomi R. Wray; Peter M. Visscher; Paul I. W. de Bakker; Michael A. van Es; R. Jeroen Pasterkamp; Cathryn M. Lewis; Gerome Breen; Ammar Al‐Chalabi; Leonard H. van den Berg; Jan H. Veldink

doi:10.1038/ng.3622

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

PARALS Registry(University Medical Center Utrecht), Wouter van Rheenen(King's College London), SLALOM Group(University Medical Center Utrecht), SLAP Registry(Trinity College Dublin), NNIPPS Study Group(University Medical Center Utrecht), Aleksey Shatunov(King's College London), Annelot M. Dekker(University Medical Center Utrecht), Russell L. McLaughlin(University Medical Center Groningen), Frank P. Diekstra(King's College London), Sara L. Pulit(The University of Queensland), Rick A. A. van der Spek(The University of Queensland), Urmo Võsa(University Medical Center Groningen), Simone de Jong(King's College London), Matthew R. Robinson(The University of Queensland), Jian Yang(The University of Queensland), Isabella Fogh(King's College London), Perry Tc van Doormaal(King's College London), Gijs Tazelaar(King's College London), Max Koppers(University of Massachusetts Chan Medical School), Anna M. Blokhuis(University Medical Center Utrecht), William Sproviero(King's College London), Ashley R Jones(King's College London), Kevin P. Kenna(University of Massachusetts Chan Medical School), Kristel R. van Eijk(University Medical Center Utrecht), Oliver Harschnitz(University Medical Center Utrecht), Raymond D. Schellevis(Trinity College Dublin), William J. Brands(University of Milan), Jelena Medic(King's College London), Androniki Menelaou(Jožef Stefan Institute), Alice Vajda(University of Ljubljana), Nicola Ticozzi(University of Ljubljana), Kuang Lin(King's College London), Boris Rogelj(Ljubljana University Medical Centre), Katarina Vrabec(University of Ljubljana), Metka Ravnik‐Glavač(University of Ljubljana), Blaž Koritnik(Centre National de la Recherche Scientifique), Janez Zidar(Centre National de la Recherche Scientifique), Lea Leonardis(Ljubljana University Medical Centre), Leja Dolenc Grošelj(University of Lisbon), Stéphanie Millecamps(Centre National de la Recherche Scientifique), François Salachas(Centre National de la Recherche Scientifique), Vincent Meininger(Universitat Autònoma de Barcelona), Mamede de Carvalho(University of Lisbon), Susana Pinto(Mott MacDonald (United Kingdom)), Jesús S. Mora(Mott MacDonald (United Kingdom)), Ricardo Rojas-García(Universitat Autònoma de Barcelona), Meraida Polak(Emory University), Siddharthan Chandran(Mott MacDonald (United Kingdom)), Shuna Colville(Mott MacDonald (United Kingdom)), Robert Swingler(Mott MacDonald (United Kingdom)), Karen Morrison(University of Southampton), Pamela J. Shaw(University College London), John Hardy(Sobell House), Richard W. Orrell(Motor Neurone Disease Association), Alan Pittman(King's College London), Katie Sidle(Medizinische Hochschule Hannover), Pietro Fratta(Sobell House), Andrea Malaspina(Motor Neurone Disease Association), Simon Topp(King's College London), Susanne Petri(Medizinische Hochschule Hannover), Susanne Abdulla(University of California, Los Angeles), Carsten Drepper(University of California, Los Angeles), Michael Sendtner(University of California, Los Angeles), Thomas Meyer(University of California, San Francisco), Roel A. Ophoff(University of California, Los Angeles), Kim A. Staats(University of California, Los Angeles), Martina Wiedau‐Pazos(University of California, Los Angeles), Catherine Lomen‐Hoerth(University of California, San Francisco), Vivianna M. Van Deerlin(Boğaziçi University), John Q. Trojanowski(Boğaziçi University), Lauren Elman(Boğaziçi University), Leo McCluskey(Istanbul University), A. Nazlı Başak(Helmholtz Zentrum München), Ceren Tunca(Helmholtz Zentrum München), Hamid Hamzeiy(Helmholtz Zentrum München), Yeşim Parman(Université de Tours), Thomas Meitinger(Université de Tours), Peter Lichtner(Helmholtz Zentrum München), Milena Radivojkov‐Blagojevic(Universität Ulm), Christian Andrés(Université de Tours), Cindy Maurel(Université de Tours), Gilbert Bensimon(Centre National de la Recherche Scientifique), G. Bernhard Landwehrmeyer(Universität Ulm), Alexis Brice(Centre National de la Recherche Scientifique), Christine Payan(Christian-Albrechts-Universität zu Kiel), Safaa Saker-Delye(Centre National de la Recherche Scientifique), Alexandra Dürr(Christian-Albrechts-Universität zu Kiel), Nicholas Wood(Heidelberg University), Lukas Tittmann(University of Bonn), Wolfgang Lieb(University of Bonn), André Franke(Inserm), Marcella Rietschel(Inserm), Sven Cichon(University of Bonn), Markus M. Nöthen(University of Bonn), Philippe Amouyel(Inserm), Christophe Tzourio(Inserm), Jean‐François Dartigues(Harvard University), André G. Uitterlinden(King's College London), Fernando Rivadeneira(Erasmus MC), Karol Estrada(Erasmus MC), Albert Hofman(Harvard University), Charles Curtis(King's College London), Hylke M. Blauw(Kantonsspital St. Gallen), Anneke J. van der Kooi(King's College London), Marianne de Visser(King's College London), An Goris(Fondazione Istituto Neurologico Nazionale Casimiro Mondino), Markus Weber(Kantonsspital St. Gallen), Christopher E. Shaw(King's College London), Bradley Smith(King's College London), Orietta Pansarasa(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Cristina Cereda(University of Padua), Roberto Del Bo(University of Padua), Giacomo P. Comi(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Sandra D’Alfonso(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Cinzia Bertolin(University of Padua), Gianni Sorarú(University of Padua), Letizia Mazzini(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Viviana Pensato(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Cinzia Gellera(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Cinzia Tiloca(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Antonia Ratti(University of Milan), Andrea Calvo(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Cristina Moglia(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Maura Brunetti(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico), Simona Arcuti(Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda), Rosa Capozzo(University of Bari Aldo Moro), Chiara Zecca(University of Bari Aldo Moro), Christian Lunetta(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico), Silvana Penco(Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda), Nilo Riva, Alessandro Padovani(University of Brescia), Massimiliano Filosto(University of Brescia), Bernard Müller(Macquarie University), Robbert Jan Stuit(Macquarie University), Ian P. Blair(The University of Sydney), Katharine Zhang(Macquarie University), Emily P. McCann(The University of Sydney), Jennifer A. Fifita(The University of Sydney), Garth A. Nicholson(The University of Sydney), Dominic B. Rowe(Jena University Hospital), Roger Pamphlett(The University of Sydney), Matthew C. Kiernan(The University of Sydney), Julian Großkreutz(Jena University Hospital), Otto W. Witte(Jena University Hospital), Thomas Ringer(Jena University Hospital), Tino Prell(Brighton and Sussex Medical School), Beatrice Stubendorff(Jena University Hospital), Ingo Kurth(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Christian A. Hübner(Mario Negri Institute for Pharmacological Research), P. Nigel Leigh(Brighton and Sussex Medical School), Federico Casale(University of Turin), Adriano Chiò(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Ettore Beghi(King's College London), Elisabetta Pupillo(Mario Negri Institute for Pharmacological Research), Rosanna Tortelli(Universität Ulm), Giancarlo Logroscino(VIB-KU Leuven Center for Brain & Disease Research), John Powell(King's College London), Albert C. Ludolph(University Medical Center Groningen), Jochen H. Weishaupt(Broad Institute), Wim Robberecht(University of Massachusetts Chan Medical School), Philip Van Damme(Emory University), Lude Franke(University Medical Center Groningen), Tune H. Pers(Broad Institute), Robert H. Brown(University of Massachusetts Chan Medical School), Jonathan D. Glass(Université de Tours), John E. Landers(Université de Tours), Orla Hardiman(University of Milan), Peter M. Andersen(The University of Queensland), Philippe Corcia(Université de Tours), Patrick Vourc’h(Université de Tours), Vincenzo Silani(University of Milan), Naomi R. Wray(The University of Queensland), Peter M. Visscher(Translational Research Institute), Paul I. W. de Bakker(King's College London), Michael A. van Es(King's College London), R. Jeroen Pasterkamp(University Medical Center Utrecht), Cathryn M. Lewis(King's College London), Gerome Breen(King's College London), Ammar Al‐Chalabi(King's College London), Leonard H. van den Berg(University Medical Center Utrecht), Jan H. Veldink(University Medical Center Utrecht)

Nature Genetics

July 25, 2016

10.1038/ng.3622

Cited by 625Open Access

Full Text

Abstract

Related Papers

No related papers found

Powered by citation graph analysis