Response to 5‐azacytidine in a patient with <i>TET2</i>‐mutated angioimmunoblastic T‐cell lymphoma and chronic myelomonocytic leukaemia preceded by an EBV‐positive large B‐cell lymphoma

Colombe Saillard(Délégation Paris 5), Hélène Guermouche(Délégation Paris 5), Coralie Derrieux(Délégation Paris 5), Julie Bruneau(Délégation Paris 5), Laurent Frenzel(Délégation Paris 5), Lucile Couronné(Délégation Paris 5), Vahid Asnafi(Délégation Paris 5), Elizabeth Macintyre(Délégation Paris 5), Amélie Trinquand(Délégation Paris 5), Ludovic Lhermitte(Délégation Paris 5), Thierry Jo Molina(Délégation Paris 5), Felipe Suárez(Délégation Paris 5), François Lemonnier(Délégation Paris 5), Olivier Kosmider(Délégation Paris 5), Richard Delarue(Délégation Paris 5), Olivier Hermine(Délégation Paris 5), Morgane Cheminant(Délégation Paris 5)
Hematological Oncology
June 29, 2016
10.1002/hon.2319
Cited by 46

Abstract

We report the case of a patient with a history of Epstein-Barr virus-positive large B-cell lymphoma, who relapsed with an angioimmunoblastic T-cell lymphoma (AITL) associated with a chronic myelomonocytic leukaemia (CMML). We performed targeted next-generation sequencing on CMML and AITL DNA, which revealed mutations of TET2, DNMT3A, SRSF2, NRAS and IDH1, thus confirming that the spectrum of AITL mutations share similarities with myeloid disorders. The frequencies of TET2/DNMT3A and SRSF2 variants could support the hypothesis that TET2/DNMT3A mutations occurred in an early progenitor cell, which later progressed to both the AITL and CMML clones. Treatment with 5-azacytidine led to the complete remission of both diseases. Thus, targeting DNA methylation abnormalities in AITL may be an alternative strategy to chemotherapy. Copyright © 2016 John Wiley & Sons, Ltd.

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