Assessing the global threat from Zika virus
Justin Lessler(Johns Hopkins University), Lelia H. Chaisson(Johns Hopkins University), Lauren M. Kucirka(Johns Hopkins University), Qifang Bi(Johns Hopkins University), Kyra H. Grantz(University of Florida), Henrik Salje(Johns Hopkins University), Andrea C. Carcelen(Johns Hopkins University), Cassandra T. Ott(Johns Hopkins University), Jeanne S. Sheffield(Johns Hopkins University), Neil M. Ferguson(Imperial College London), Derek A. T. Cummings(University of Florida), C. Jessica E. Metcalf(Princeton University), Isabel Rodríguez-Barraquer(Johns Hopkins University)
Cited by 409Open Access
Abstract
First discovered in 1947, Zika virus (ZIKV) infection remained a little-known tropical disease until 2015, when its apparent association with a considerable increase in the incidence of microcephaly in Brazil raised alarms worldwide. There is limited information on the key factors that determine the extent of the global threat from ZIKV infection and resulting complications. Here, we review what is known about the epidemiology, natural history, and public health effects of ZIKV infection, the empirical basis for this knowledge, and the critical knowledge gaps that need to be filled.
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