Neuroinflammation pathways: a general review

Tara Shabab(University of Malaya), Ramin Khanabdali(University of Melbourne), Soheil Zorofchian Moghadamtousi(University of Malaya), Habsah Abdul Kadir(University of Malaya), Gokula Mohan(University of Malaya)
International Journal of Neuroscience
July 14, 2016
10.1080/00207454.2016.1212854
Cited by 614

Abstract

Activated microglial cells play an important role in immune and inflammatory responses in central nervous system and neurodegenerative diseases. Many pro-apoptotic pathways are mediated by signaling molecules that are produced during neuroinflammation. In glial cells, NF-κB, a transcription factor, initiates and regulates the expression of several inflammatory processes during inflammation which are attributed to the pathology of the several neurodegenerative diseases. In this review, we discuss the most important neuroinflammatory mediators with their pathways. Attenuating cytokines production and controlling microglial inflammatory response, which are the result of understanding neuroinflammation pathways, are considered therapeutic strategies for treating neurodegenerative diseases with an inflammatory component.

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