Production of Human Antibodies from Transgenic Mice

Abstract

Mice transgenic for human immunoglobulin genes offer the opportunity to investigators to derive fully human antibodies using well-established hybridoma technology. Several different strains of such mice are available, and can be obtained under certain conditions from various commercial entities (1–3). The brand names of these mice include XenoMouse®, HuMAb® Mouse, TC™ mouse, and KM™ mouse. The leading transgenic mice all share certain properties. These include the following: