Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys
Rainer E. Martin(Roche (Switzerland)), A. Mayweg(Roche (Switzerland)), André Alker(Roche (Switzerland)), Xuefei Tan(Roche (China)), Philippe Verry(Roche (Switzerland)), William Riboulet(Roche (Switzerland)), Giorgio Ottaviani(Roche (China)), Bernd Kuhn(Roche (Switzerland)), Hans Peter Märki(Roche (Switzerland)), Dominique Burger(Roche (Switzerland)), Hans-Jakob Krebs(Roche (Switzerland)), A. Kuglstatter(Roche (Switzerland)), Stephan Müller(Roche (Switzerland)), Kurt E. Amrein(Roche (Switzerland)), Johannes D. Aebi(Roche (Switzerland)), Benoit Hornsperger(Roche (Switzerland))
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